Well, I finally got around to downloading 4DO. I'm very impressed with the format and user interface, and I gotta say, I really love the controller config. With most emulators I have to redo the configuration every time because I can't remember what I had previously set the buttons to.
The first game I tried running was the USA version of Strahl. This is straight from the game disc, so no possibility of a bad Rom. Though 4DO's compatibility list
marks Strahl as 100% compatible, there are at least two major problems with it. During the introductory cutscene, immediately following the words "Dare ye", the emulator suddenly struggles and then skips over the rest of the scene, jumping immediately to the stage select intro. Then, at the words "is sealed the origin", the same thing happens, and the rest of the intro is skipped.
I tried fooling around a bit - just resets and save states - but I couldn't get the emulator to play the rest of those scenes. I've seen the exact same thing on a YouTube playthrough of the game, too, so apparently it's a common problem.