Ok time for me to bust in on this the best I can, first according to critics and popularity:
1. Star Control II (not my opinion but has been the general consensus for some time, I still love it though

)
2. Need for Speed (I have no interest in this game, but it was still huge)
3. Road Rash (I don't care for it but it got rave reviews)
4. Space Hulk ( I never played it but it got top reviews over time)
5. Samurai Shawdown
6. Out Of This World (one of my favorites)
7. Killing Time (one of my favorites)
8. Street Fighter 2 Turbo (I like

)
9. Alone In The Dark (one of my favorites)
10. Wing Commander III
11. The Horde (one of my favorites

)
12. Gex
13. Shockwave 2 (I don't like it)
14. Wolfenstein 3D (love it

)
15. Return Fire
16. Captain Quazar
17. Escape from Monster Manor (yuck!)
18. Soccer Kid
19. Slayer (Blah!

)
20. D
Now my personal opinion
1. Lost Files Of Sherlock Holmes
2. Killing Time
3. Alone In The Dark
4. The Horde
5. Shockwave 1
6. Out Of This World
7. Twisted
8. Wolfenstein 3D
9. Street Fighter II Turbo
10. Demolition Man (underrated for 3DO)
11. Foes Of Ali
12. Myst
13. Battle Chess
14. Captain Quazar
15. Gex
I only have a top 15 for my personal list, I have not explored that many titles, and many I don't even want to, even though I love the 3DO and certain 3DO games I love to death, most games just suck
